Lipotoxicity and hypoxia in NAFLD
Hosted by JC Fernández-Checa
The LiverSeminars Program is an educational activity in which experts in the Hepatology field will come to one of the two organizing institutions (IDIBAPS in Barcelona, IiSGM in Madrid) to spend a whole day sharing basic and translational science.
Visits will always have the same agenda: during the morning, the Expert will be able to meet in private with scientists from research centres geographically close to the Institution that welcomes him (please book your time slot at the “meet the speaker” tab), in the afternoon we will have the seminar itself that will be live broadcasted to the Institute that does not host the speaker.
Please note that activities are not restricted to the personnel from the organizing institutions. In this page you will find detailed information about the invited Speakers and scientific topics that will be covered during this academic year.
Dr. Oren Tirosh received his Ph.D. from the School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem in 1997. He did his postdoctoral training with Lester Packer at the University of California at Berkeley. Since 2001 he has been a staff member of the Institute of Biochemistry, Food Science and Nutrition, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem. At the year 2011 he was appointed the head of the School of Nutrition. Dr. Tirosh holds life time honorary membership in the Oxygen Club of California. His research interests include studying nitric oxide biology, oxidative stress, hypoxic signaling and lipid metabolism in the liver and the health effect of the Mediterranean diet. Dr. Oren Tirosh is known for his studies regarding diet-induced stabilization of hypoxia inducible factor 1alpha and the connection to glucose metabolism, NASH and fibrosis. He has demonstrated that in steatotic hepatocytes hypoxia can cause perinuclear mitochondrial localization, lipid peroxidation and nuclear oxidative stress, which can lead to impaired gene expression during fatty liver disease. Latest evidence to be presented are studies regarding interactions of specific bile acids in the presence and absence of cholesterol, and their effect on liver regeneration, damage and fibrosis.
Find below the video recording as soon as it is available.