From organoids to organs – a journey of clinical translation

Hosted by Pedro Baptista

Fotios Sampaziotis is a UK Research and Innovation (UKRI) Future Leaders Fellow at the University of Cambridge and an honorary consultant hepatologist in Addenbrooke’s hospital. He obtained his medical degree from the University of Athens and completed his hepatology clinical training in Cambridge. In parallel, he secured an MRC Clinical Research Training Fellowship towards a PhD degree in the Cambridge Stem Cell Institute and continued his post-doctoral research as an NIHR Clinical Lectureship in Hepatology with Prof Ludovic Vallier in Cambridge.

Fotios’ research combines cholangiocyte biology, bioengineering and regenerative medicine to develop new therapies for biliary disease. He is a founding member of the European Association for the Study of Liver (EASL) Regenerative Hepatology Consortium.

About this LiverSeminar: Biliary disorders are a leading cause for transplantation in children and adults, with minimal alternative therapies for end stage disease. This presentation focuses on how primary cholangiocytes, propagated as organoids in vitro, can help address this challenge. Key applications of these organoids will be outlined, including studies in biliary physiology, disease modelling and drug screening with particular emphasis on bioengineering and regenerative medicine.