SINGLE CELL TRANSCRIPTOMICS TO STUDY LIVER AGEING

Hosted by Javier Cubero

Ignacio Benedicto studied Biochemistry at Universidad Complutense de Madrid, including one year at Aarhus University (Denmark) under the ERASMUS fellowship program. He obtained his PhD at Universidad Autónoma de Madrid, where he studied the alteration of hepatocyte intercellular junctions induced by hepatitis C virus infection, and how the virus hijacks the molecular machinery that controls epithelial polarity. His predoctoral period included short research stays at University of Virginia (USA), University of Lyon (France) and Centro de Investigación en Medicina Aplicada (CIMA) (Pamplona, Spain). During his postdoctoral stay at Dr. Enrique Rodriguez-Boulan’s lab (Weill Cornell Medical College, New York) he studied how the crosstalk between endothelial cells and the retinal pigment epithelium modulates the establishment of the outer blood-retinal barrier in the eye. He also carried out single cell transcriptomics to investigate the immunomodulatory role of endothelial cells in the eye and the impact of endothelial ageing on eye homeostasis. In 2018 he obtained the grant “Atracción de Talento Investigador-Modalidad 1” (Comunidad Autónoma de Madrid) and joined the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid. Currently, he is interested in studying the impact of endothelial aging on vascular intercellular crosstalk, and its implications for atherosclerosis, liver regeneration and fibrosis.