Hosted by Silvia Affò
Dr. Schwabe’s laboratory studies the mechanisms of chronic liver disease and liver cancer with a particular interest in cell-cell communication and targetable pathways. The Schwabe lab has demonstrated that hepatic stellate cells represent the major fibrogenic cell population in the liver and shown key roles for hepatic stellate cells and hepatic stellate cell-derived mediators in the development of liver cancer. Recent studies in the Schwabe lab investigate the hypothesis that the primary function of hepatic stellate cells is protective and that the balance between protective and disease-promoting pathways dictates the influence of HSCs in chronic liver disease and cancer. Moreover, the Schwabe lab also studies gene regulatory networks in liver cancer with the goal to discover novel therapeutic vulnerabilities and combination therapies.