Cellular Interactions in liver injuries and regeneration – focus on the portal area

Group leader at the Charité university of medicine Berlin

Dr. Adrien Guillot is a research group leader at the Charité university of medicine Berlin, Berlin (Germany), in the department of hepatology and gastroenterology led by Prof. Frank Tacke. He received his Ph.D. at the University Paris-East Créteil (France) where he studied the roles of interleukin-17A in liver pathogenesis and liver regeneration through ductular reaction, under the supervision of Prof. Fouad Lafdil and in the INSERM team led by Dr. Sophie Lotersztajn. He pursued with a four-year postdoctoral experience at the National Institutes of Health (NIH, U.S.A.), where he conducted two projects related 1/ to targeting liver acetaldehyde dehydrogenase 2 in alcohol use disorders, and 2/ to monocyte/macrophage response to acute biliary epithelial cell injury. Dr. Guillot then joined the laboratory of Prof. Frank Tacke as a postdoctoral fellow with the support of the Alexander von Humboldt Foundation, before being promoted junior research group leader in that same department. His international research group now focuses on dissecting the intricate cell-cell interactions involved in liver disease progression, with a particular focus on the events taking place in the liver portal area. Alongside, Dr. Guillot is optimizing methods related to multiplex immunofluorescence and digital image analyses, as well as liver-on-a-chip multicellular models. He is member of the editorial boards of JHEP Reports and eGastroenterology and reviewer for leading journals in the field. Dr. Guillot is also active on science advocacy at the European level.